Botox vs. Dysport vs. Xeomin

Differentiate the use of Neurotoxins in Facial Aesthetics

When it comes to wrinkle relaxers, the common question asked is, "What is the difference between Botox (OnabotulinumtoxinA), Xeomin (IncobotulinumtoxinA), or Dysport (AbobotulinumtoxinA)?". It is understandable why the patient would want to know about Botox, Dysport, and Xeomin when trying to determine which treatment is best for them. All of them are derived from the same source of bacterium clostridium botulinum. They are then synthesized as botulinum toxin type A, the paralyzing agent or neurotoxin that is finally administered. Each has been consistently proven in clinical trials for overall worldwide application. The result is almost always the same: each injectable- Botox, Xeomin, or Dysport, temporarily paralyzes the targeted muscle areas on the face to relax and ease out the appearance of laugh lines, fine lines, and wrinkles, making the patients look and feel younger. Due to their proven abilities, these wrinkle relaxers when paired with the power of dermal fillers like Juvéderm or Restylane, patients can have an overall facial rejuvenation experience.

At Aesthetic Academy Asia, we have a team of Certified doctors that impart comprehensive clinical knowledge and hands-on training to doctors, dentists, Aesthetic Nurses, Aestheticians, and spa owners in the field of Aesthetic medicine. Aesthetic Academy Asia is based in Malaysia and receives Aesthetic students from the Philippines, Myanmar, Cambodia, India, Indonesia, and other parts of Asia. Assoc. Prof Dr. Morthy is the lead trainer and course director for the region. He is also the medical director of Global Aesthetic ( which offers advanced Aesthetic medical procedures. Aesthetic Academy Asia with the insignia of “Be Certified, Be Recognized” has always stressed the importance of structured Aesthetic medical education with international recognition for those opting for a career in Aesthetic Medicine. Under our European certification programme in Aesthetic Medicine and our International Online Aesthetic courses, Aesthetic students are trained extensively to provide safe, effective, and perfect results. When administered by a knowledgeable individual with proper training under the advanced Botox and Dysport training course, the risks of injecting these neuromodulators can be minimized while maximizing the benefits, which is what Aesthetic Academy Asia aims at.

In today’s article, we will broach upon the subject of Botox, Xeomin, and Dysport, to determine which treatment is the best for them under the advanced Botox and Dysport training course, along with the importance of training.

How Botox, Dysport, and Xeomin work

To begin with, cosmetic treatments using botox, Dysport, and Xeomin are different from one another to cater to each patient’s specific need so it’s important that we understand what it does before the start of any procedure.

As one gets older, fine lines and wrinkles on the face, around the eyes, and on the forehead become more noticeable. At first, they only appear when people express themselves by frowning or laughing. However, as one ages, those lines become more present, even when the faces are at rest. Dynamic wrinkles are a result of repeated facial movements that form creases or lines in the skin. Wrinkle relaxers or neuromodulator injections with Botox, Dysport, and Xeomin can reduce the appearance of dynamic wrinkles and help the patients achieve a smoother, refreshed more youthful facial look. A neuromodulator is a form of botulinum toxin type A when administered blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterized by excessive cholinergic neuronal activity. As they temporarily paralyze the nerve impulses that provide muscle movement to make certain facial expressions, contraction-induced wrinkles are eliminated or greatly reduced. This procedure should only be performed by a trained doctor with a sound understanding of Human Anatomy.

Common facial areas where wrinkle relaxers/neuromodulators help include- eyes (crow's feet), forehead lines. eyebrow lift, glabellar or frown lines ("11" lines), Nasalis muscle (bunny lines), and dimpled chin.

 Advanced Botox Dysport Training


Difference between Botox, Dysport, and Xeomin

Botulinum neurotoxins (BoNTs) are a well-established treatment option for disorders such as dystonia or spasticity, as well as for aesthetic facial treatments. BoNTs cause temporary muscle relaxation, which can ease symptoms and aid rehabilitation when injected into specific muscles of patients suffering from movement disorders. This action is a result of their potent ability to inhibit neurotransmitter release, which causes flaccid paralysis. This action underpins the therapeutic and aesthetic use of the toxin. BoNT also inhibits acetylcholine release at autonomic nerve terminals and is used in hyperhidrotic and urological disorders

There are multiple serotypes of BoNTs. Currently, all but one of the therapeutic BoNT products are botulinum neurotoxin type-A (BoNT-A). At present, there are three BoNT-A products available worldwide: abobotulinumtoxinA (Dysport), onabotulinumtoxinA (Botox), and incobotulinumtoxinA (Xeomin).

Botox and Dysport contain accessory or complexing proteins in addition to the neurotoxin. They are considered "heavier" because they contain these added proteins, yet they add the benefit of clustering around the neurotoxin substance, enabling it to last longer. It helps deliver the neurotoxin substance to the targeted area. Xeomin contains no such accessory protein, making it a pure injectable form of botulinum toxin. This allows for less risk of patient rejection or an allergic reaction due to the absence of an additional protein additive.

Dysport is known to have more diffusion, so better distribution underneath the skin. It is often used to tackle smaller, fine lines in one area like crow's feet or handle a larger area than needed several injections since it spreads easily. Dysport usually requires more units per dosage, but generally is lower in cost than Botox. Generally, most patients see their Dysport results in 3 – 5 days approximately, so it has a quick onset after being injected. It is ideal for patients wanting faster results. Botox and Xeomin are similar and more effective at correcting a rogue wrinkle or crease, for instance, on the forehead or brow area. Botox is typically considered the best option, in particular, for deeper wrinkles. Botox and Xeomin take about 1 – 2 weeks approximately for the full treatment to take hold and typically last longer than Dysport.

In the battle of which wrinkle relaxers/neuromodulator is the best, there is no clear winner. All three are highly effective at reducing the appearance of laugh lines, fine lines, and wrinkles. A skilled injector trained under the advanced Botox and Dysport training course can get excellent results with all three.

Why is Botulinum Toxin training important?

Injecting neuromodulators should be performed under certified aesthetic practitioners who are trained individuals skilled to perform procedures with adequate knowledge about the treatment. This is crucial because when injected, these neuromodulators can cause allergic reactions, infections, and the death of skin cells. Another risk is that improper injection technique can lead not only to swelling and lumpiness, but also more serious side effects such as the death of skin cells, and embolism leading to blindness.

Before you start the cosmetic procedure, ask yourself few questions-

  1. Can you do Botox, Dysport, or Xeomin around the mid-face area?

  2. Where should Neurotoxins (Botox, Dysport, or Xeomin) be injected to?

  3. Is the effect of Neurotoxins (Botox, Dysport, or Xeomin) longer-lasting or Temporary?

  4. Lastly, which type of neuromodulator are you going to use? Botox, Dysport or Xeomin?

In order to deliver a safe and effective result, the injector must know the anatomy of the human body. This includes histology, anatomical descriptions, lymphatic and blood supply. Next will be the type of neuromodulators available in the market and to choose the one that suits the patient. Lastly, the injector must know the complications, identify them, avoid and manage if it occurs.

At Aesthetic Academy Asia, the Aesthetic doctors, Aesthetic Nurses, Aestheticians, spa owners & Aesthetic dentists are intensively trained in theory as well as clinical skills under our advanced Botox and Dysport training course, so that they can understand the basic principles of neuromodulators and execute the cosmetic procedure, safely and effectively.

The advanced Botox and Dysport training course curriculum include:

  • What are the suitable neuromodulators available and why?

  • How to inject a neuromodulator?

  • What are various complications that may arise during the course of treatment?

  • How to avoid those complications?

  • How to treat those complications?

Aesthetic education at Aesthetic Academy Asia

At renowned Aesthetic Academy Asia, may it be for students from the Philippines, Myanmar, India, Cambodia, Indonesia, or any part of the world, we take Aesthetic education with utmost seriousness and help our students learn and practice effective Aesthetic procedures so they are confident enough to start their career in Aesthetic. Our students are well versed to handle any situation, simply because we focus on teaching the fundamentals and principles of the Aesthetic procedures before venturing into clinical skills. Our students learn advanced and new skills and techniques that are different than the textbooks under our best cosmetology courses. We teach them safe, effective, and affordable ways to perform Aesthetic procedures.

In addition to the Professional Diploma in Aesthetic Medicine for Doctors & Dentists and Professional Certificate in Advanced Aesthetic for Nurses, Aestheticians and Spa Owners, Aesthetic Academy Asia also conducts specialized and advanced training such As Non-Surgical Body Sculpting, Dermal Filler (Restylane, Juvéderm, Teosyal, Bellotero), Botulinum Toxin (Botox, Dysport, Xeomin), Skin Boosters (Restylane Skin Booster, Profhilo, Rejuran) Platelet Rich Plasma (PRP), Threadlift (PDO, Aptos, Happy Lift) and more. Now with the current pandemic, the Academy is conducting an online Professional Diploma in Aesthetic Medicine and an online Professional Certificate in Advanced Aesthetic courses using state-of-the-art virtual meeting technology.

The Academy has produced some of the finest Aesthetic graduates in the world who have graduated from our professional aesthetic courses with dual international certificates.

(Read more- How safe is Botox?)